C.J. Stroud will be looking for redemption after last year's loss to Michigan.
C.J. Stroud will be looking for redemption after last year's loss to Michigan.

College Football Week 13 Betting Cheat Sheet: Breaking Down Every Key Matchup

Thanksgiving week also means rivalry week in college football. There are a number of fun matchups around the country this weekend but only three that stand above the rest as marquee games. Below you’ll find betting information and edges in regard to the trio of games that could have major College Football Playoff implications.

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No. 3 Michigan (11-0, 6-4-1) vs. No. 2 Ohio State (11-0, 5-5-1)

Moneyline: Michigan +240, Ohio State -305

Spread: Ohio State -7.5

Total: 57.0

One of the biggest rivalries in all of sports also happens to be one of the most crucial regular season games of the college football season. The winner will lock up a spot in the College Football Playoff. The bigger question is whether the loser will still have a chance to make the field of four as a one-loss team without a chance to play in a conference championship game. My gut says that a close game would result in both teams being in, especially if it’s Michigan hanging around as a 7.5-point road underdog.

Michigan is 3-1-1 ATS in its last five games. Ohio State is just 1-3 ATS in its last four games. The Buckeyes are 4-1 against the Wolverines in the last five meetings, but Michigan is 3-2 ATS.

The Wolverines could be without star running back Blake Corum, who injured his knee in last week’s narrow win over Illinois. That would be a brutal loss given Michigan relies so heavily on its running game and ranks fourth in the country in rushing yards. Quarterback J.J. McCarthy and the Michigan passing attack have been far less potent, ranking 100th in passing yards. That gives a huge edge to an Ohio State defense that ranks 11th in passing yards allowed, surrendering just 175.5 per game.

Michigan’s defense will have to be dominant, just as it has been all season. The Wolverines rank second in scoring defense and first in total yards allowed. It figures to be an incredible strength-on-strength matchup against Heisman favorite C.J. Stroud and Ohio State’s second-ranked scoring offense.

No. 10 Oregon (9-2, 8-3 ATS) vs. No. 22 Oregon State (8-3, 9-2 ATS)

Moneyline: Oregon -155, Oregon State +130

Spread: Oregon -3.0

Total: 58.0

Oregon’s hopes of reaching the CFP are gone, but a win over Oregon State would still clinch a spot in the Pac-12 Championship Game against USC with a chance to reach the Rose Bowl. The Ducks narrowly escaped Utah last Saturday due in large part to the performance of their defense. Bo Nix is dealing with a right leg injury that may hamper him for the remainder of the season.

Points won’t come easy against a Beavers defense that is one of the best in the conference, ranking 28th in the nation in points allowed and 25th in total yards allowed. The combination of Nix’s injury and being on the road is why Oregon is just a narrow favorite in this one despite possessing the fourth-ranked scoring offense.

Oregon State has been one of the most profitable teams in college football this season having covered five straight spreads. It has been the Ducks who have dominated this head-to-head matchup of late with a 4-1 record (3-2 ATS) in the last five meetings.

No. 13 Notre Dame (8-3, 6-5 ATS) vs. No. 5 USC (10-1, 7-4 ATS)

Moneyline: Notre Dame +180, USC -220

Spread: USC -5.0

Total: 64.5

It has been a bizarre season for the Irish with one signature win, blowing out Clemson 35-14, and a pair of egregious losses to Stanford and Marshall. Notre Dame also narrowly beat Navy, 35-32, despite being 17-point favorites.

USC is coming off a thrilling, 48-45 win over UCLA. The Trojans have already clinched a spot in the Pac-12 title game with the chance for two more signature wins against Notre Dame and whoever meets them in the Pac-12 Championship game.

The Irish have won four straight games against USC.

This one will be a strength-on-strength game with a mediocre Notre Dame offense against a pedestrian USC defense that just got torched all game by UCLA. On the other side, USC’s third-ranked scoring offense led by Caleb Williams will face a Notre Dame defense that ranks 29th in points allowed.

Given all that’s at stake for USC, coupled with the fact that they’re at home, it’s hard to imagine the Trojans having a letdown game. However Notre Dame will attempt to play spoiler all the same.